If you’ve been looking into weight loss options, you’ve probably heard about Saxenda. It’s a pretty popular prescription medication that’s been helping a lot of people shed those extra pounds. But let’s face it, not everyone can get their hands on it – maybe it’s too expensive, or you can’t get a prescription, or you’re just not comfortable with injection medications.

That’s where natural OTC alternatives come in. We’re talking about over-the-counter options that might give you some of the benefits of Saxenda without the need for a doctor’s prescription. Now, I’m not saying these are exact copies of Saxenda – they’re not. But they’re designed to help with weight loss in similar ways.

In this article, I’m going to introduce you to the top natural alternatives to Saxenda that you can buy over the counter or online. We’ll look at supplements that aim to mimic the effects of liraglutide (that’s the active ingredient in Saxenda) and other substitutes that might help you on your weight loss journey.

3 Natural Over the Counter Alternatives to Saxenda

Here are 3 natural appetite suppressant supplements that are recognized in the industry as being among the most effective for managing body weight and work in a similar way to Saxenda (Liraglutide injections)

1. PhenQ – Appetite Suppressant and Fat Burner
2. Keto Charge – Ketogenic Diet Pill
3. Gluconite – Blood Sugar Management

All 3 brands are available to order directly without prescription from the manufacturer and have long money back guarantees.

More In-depth Look at the 3 Best Natural Saxenda Substitutes

Here is a more detailed review of the natural options you can use to lose weight if you want to avoid injectable weight loss medication like Saxenda.

#1 – PhenQ

VIEW PhenQ pricing and special promotions from the official website

What is PhenQ?

PhenQ is an over-the-counter weight loss supplement that is great for losing weight through multiple ways. It combines several natural ingredients in a proprietary blend to boost metabolism, burn fat and suppress appetite.

Clinical studies have shown that users of PhenQ can achieve an average weight loss of X% over Y weeks.

How does PhenQ work?

PhenQ works in several ways:

1. Thermogenesis: α-Lacys Reset® and capsicum extract may increase body temperature and burn more calories.
2. Appetite suppression: Nopal cactus fiber and chromium picolinate may control hunger and reduce cravings.
3. Fat blocking: It may prevent new fat cells from forming.
4. Energy boost: Caffeine and other ingredients give you energy to be more active.
5. Mood enhancement: Some ingredients may balance your mood and reduce emotional eating.

Why choose PhenQ over Saxenda?

While Saxenda is a prescription drug, PhenQ has many advantages:

• No prescription required
• Cheaper
• Fewer side effects
• Targets multiple weight loss areas
• Can be bought online
• Natural ingredients
• Helps prevent weight gain by suppressing appetite and boosting metabolism

However please note that PhenQ is not a replacement for prescription drugs like Saxenda which are designed for specific medical conditions.

Pros and Cons

Pros:

• Multi weight loss approach
• Natural ingredients
• No prescription needed
• Generally safe
• Money back guarantee by manufacturer

Cons:

• Doesn’t ship to some countries
• Not for pregnant or breastfeeding women

Where to buy

PhenQ can be bought directly from the official website which sometimes offers discounts for bulk orders and money back guarantee. Not available in physical stores or other online retailers to ensure product authenticity.

#2 – Keto Charge

View Keto Charge official website and see current price and discounts

What is Keto Charge?

Keto Charge is a supplement for people on a ketogenic diet. It helps you get into ketosis, reduces keto flu symptoms and enhances the benefits of a low carb high fat diet. It contains a blend of electrolytes and compounds that your body can convert into ketones. Keto Charge supports the maintenance of a healthy weight by promoting ketosis and reducing cravings.

How does Keto Charge work?

Keto Charge works in several ways:

1. Ketone production: It gives your body salts that can be converted into ketones to get you into ketosis faster.
2. Electrolyte balance: Replenishes electrolytes lost during the initial stages of a ketogenic diet.
3. Energy boost: May increase energy to combat fatigue when starting a keto diet.
4. Blood sugar regulation: Helps to regulate blood sugar levels to reduce cravings and hunger.
5. Hydration support: Helps to keep you hydrated which can be hard when first adapting to a keto diet.

Why use Keto Charge instead of Saxenda?

Saxenda is a prescription weight loss medication but Keto Charge offers:

• Designed for people on a ketogenic diet
• No prescription needed
• Supports metabolic adaptation not appetite suppression
• Fewer side effects
• Available online
• Possibly cheaper

But remember Keto Charge serves a different purpose than Saxenda and is not a substitute for prescription weight loss medication.

Pros and Cons

Pros:

• Supports ketosis and keto diet
• Reduces keto flu symptoms
• No prescription needed
• Natural ingredients
• May increase energy on a keto diet

Cons:

• Only beneficial for people on a ketogenic diet
• Results may vary
• Not a standalone weight loss solution
• Not suitable for people with certain health conditions

Where to buy

Keto Charge is usually available on the official website. Buying from the manufacturer ensures product authenticity and may come with special offers or bulk discounts. Not available in physical stores or major e-commerce platforms.

#3 – Gluconite

View Gluconite current offers and special pricing from official webstore

What is Gluconite?

Gluconite is a sleep and metabolism support supplement designed for people with blood sugar concerns. It contains ingredients to support better sleep, healthy blood sugar and weight management. Take before bed. Gluconite also supports overall health by helping to manage high blood pressure and improve sleep quality.

How does Gluconite work?

Gluconite works in 5 ways:

1. Blood sugar regulation: Chromium and biotin to support healthy blood sugar.
2. Sleep enhancement: Melatonin and other sleep herbs.
3. Metabolism support: Some ingredients to boost metabolism for weight management.
4. Stress reduction: Ingredients to reduce stress and anxiety which affects sleep and blood sugar.
5. Antioxidant support: Antioxidants for overall health.

Why Gluconite over Saxenda?

Saxenda is a prescription weight loss medication. Gluconite is different:

• Focuses on sleep and nighttime metabolism
• No prescription required
• Addresses more than just weight loss
• Fewer side effects
• Over the counter
• Cheaper

But Gluconite serves a different purpose than Saxenda and is not a replacement for prescription meds.

Pros and Cons

Pros:

• Multifaceted health (sleep, blood sugar, metabolism)
• Natural ingredients
• No prescription needed
• May improve sleep
• Better blood sugar control

Cons:

• No clinical trials on the exact formula
• Results may vary from person to person
• Not a Saxenda alternative
• May interact with other meds or supplements
• Expensive compared to some other supplements

Where to buy

Gluconite can be bought from the official website. Buying from the manufacturer ensures product authenticity and may get you special offers or discounts. Not found in local stores or major online retailers.

What is Saxenda (Liraglutide)

Saxenda is a prescription medication used for chronic weight management in adults with obesity or overweight individuals with at least one weight-related comorbidity. Saxenda is typically prescribed for individuals with a body mass index (BMI) of 30 or higher, or 27 or higher with at least one weight-related comorbidity. Its active ingredient is liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist.

Saxenda works by mimicking a hormone that targets areas of the brain involved in regulating appetite and food intake. It helps to:

1. Reduce hunger
2. Increase feelings of fullness
3. Lower food cravings

Administered as a daily subcutaneous injection, Saxenda is typically used in conjunction with a reduced-calorie diet and increased physical activity. It’s considered a long-term treatment option for weight management and has shown significant results in clinical trials for weight loss and maintenance. However, it may cause side effects and requires careful medical supervision.

FDA Approval Date:
Saxenda was approved by the U.S. Food and Drug Administration (FDA) on December 23, 2014, for chronic weight management in adults.

Introduction to Market:
Following FDA approval, Saxenda was introduced to the U.S. market in early 2015. It became available for prescription use in the United States around April 2015.

Additional FDA Approvals:

• On December 4, 2020, the FDA approved an expanded indication for Saxenda to include treatment of obesity in adolescents aged 12-17 years with a body weight above 60 kg and an initial BMI corresponding to 30 kg/m² or greater for adults.

Key Points:

• Saxenda is a higher-dose formulation of liraglutide, which was already approved for type 2 diabetes treatment under the brand name Victoza (at lower doses) in 2010.
• It was the first GLP-1 receptor agonist approved specifically for chronic weight management.
• The approval was based on clinical trials showing that Saxenda, when used in conjunction with a reduced-calorie diet and increased physical activity, resulted in clinically meaningful weight loss in adults.

It’s worth noting that while Saxenda was groundbreaking at its time of approval, newer GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists have since been introduced, offering potentially greater weight loss efficacy. However, Saxenda remains an important option in the pharmacological treatment of obesity.

How Saxenda Works

Saxenda (liraglutide) works by mimicking the action of the natural hormone GLP-1 in your body. Saxenda is particularly effective for individuals with a weight-related condition such as type 2 diabetes or high blood pressure. Here’s how it works:

1. GLP-1 receptor activation: Saxenda binds to and activates GLP-1 receptors in your brain, especially in areas that control appetite and food intake.
2. Hunger reduction: It tells your brain to reduce hunger and increase feelings of fullness.
3. Delayed gastric emptying: Saxenda slows down the rate at which food leaves your stomach, so you feel fuller for longer.
4. Blood sugar control: It stimulates insulin release and reduces glucagon secretion to help regulate blood sugar levels.
5. Metabolic effects: Saxenda may affect energy expenditure and fat metabolism, but these effects are less pronounced than its effect on appetite.
6. Continuous action: As a long-acting GLP-1 analogue, Saxenda works all day long when taken once a day.

This multi-faceted approach helps users reduce calorie intake and manage weight more effectively.

Limitations, Side Effects, and Average Weight Loss of Saxenda

Limitations of Use:

• Not to be used with other GLP-1 agonists
• Not proven in children with type 2 diabetes
• Not recommended for children under 12

Common Side Effects:

• Nausea, vomiting, diarrhea, stomach pain
• Mild to severe

Serious Side Effects:

• Rare
• FDA boxed warning due to animal studies of thyroid cancer
• Contraindicated for those with medullary thyroid cancer or MEN 2

Saxenda works for weight loss but has limitations and side effects. Don’t use with other GLP-1 agonists and it’s not for kids. Common side effects are gastrointestinal and can be mild to severe. Though rare, serious side effects can happen. The FDA has a boxed warning for thyroid cancer risk based on animal studies. If you have a history of certain thyroid conditions, avoid Saxenda. As with any medication, talk to your doctor to weigh the benefits vs risks.

Cost and Insurance of Saxenda

The cost of Saxenda can vary depending on the dose, quantity, and pharmacy. On average, a 30-day supply of Saxenda can cost between $1,200 and $1,300. However, there are several ways to lower the cost of Saxenda, including insurance coverage and assistance programs.

Insurance Coverage: Saxenda may be covered by some health insurance programs, but this will depend on the specific program and insurance coverage. Patients should speak with their insurance company to determine whether the drug is covered and what their potential out-of-pocket expenses would be.

Assistance Programs: Novo Nordisk, the manufacturer of Saxenda, offers several assistance programs to help patients afford the medication. These programs include the Saxenda Savings Card, which can help patients save up to $500 per month on their prescription.

By exploring these options, patients can potentially reduce the financial burden of using Saxenda for weight management.

FDA Warning: Risk of Thyroid Cancer

Saxenda has a boxed warning for the risk of thyroid cancer in animals. It is not known if Saxenda increases the risk of thyroid cancer in humans. However, the FDA has warned that Saxenda may increase the risk of thyroid cancer, particularly in patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Symptoms of Thyroid Cancer: Patients should be aware of the symptoms of thyroid cancer, which include a lump in the neck, a hoarse voice that doesn’t go away, trouble swallowing, or shortness of breath. If patients experience any of these symptoms, they should contact their doctor immediately.

Understanding these risks and symptoms can help patients make informed decisions about their weight loss medications and seek timely medical advice if needed.

Saxenda Interactions and Precautions

Saxenda can interact with several other medications, including other GLP-1 agonists, insulin, and oral hypoglycemic agents. Patients should inform their doctor about all prescription, over-the-counter, and herbal medications they are taking before starting Saxenda.

Precautions: Saxenda is not recommended for patients with a personal or family history of medullary thyroid cancer or MEN 2. Patients with a history of pancreatitis, gallbladder disease, or kidney disease should also use caution when taking Saxenda.

By discussing your full medical history with your healthcare provider, you can ensure that Saxenda is a safe and appropriate option for your weight management needs.

Saxenda Expiration, Storage, and Disposal

Saxenda should be stored in the refrigerator at a temperature between 39°F and 46°F (4°C and 8°C). The medication should not be frozen or exposed to direct sunlight.

Expiration Date: Saxenda has an expiration date printed on the label. Patients should not use Saxenda after the expiration date.

Disposal: Saxenda should be disposed of properly to prevent accidental exposure or misuse. Patients should follow the instructions provided by their doctor or pharmacist for disposing of Saxenda.

Proper storage and disposal of Saxenda ensure the medication remains effective and safe to use, while also preventing potential harm from improper handling.

Alternative Weight Loss Medications

Prescription Alternatives

Here’s a list of 10 prescription alternatives to Saxenda.

1. Ozempic (semaglutide): A once-weekly injectable GLP-1 receptor agonist. It helps lower blood sugar and may assist with significant weight loss in type 2 diabetes patients.
2. Wegovy (semaglutide): A higher-dose version of semaglutide specifically approved for chronic weight management. It’s administered once weekly and has shown substantial weight loss results in clinical trials. When comparing Wegovy and Saxenda, Wegovy generally leads to greater weight loss but may have different side effects.
3. Mounjaro (tirzepatide): A dual GIP and GLP-1 receptor agonist that offers potent blood sugar control and weight loss effects. It’s a once-weekly injection that has shown impressive results in clinical studies.
4. Zepbound (tirzepatide): The brand name for tirzepatide when used specifically for weight loss. It’s the same medication as Mounjaro but marketed for a different primary indication.
5. Qsymia (phentermine/topiramate): A combination medication that suppresses appetite and reduces food cravings. It combines a stimulant with an anticonvulsant for enhanced weight loss effects.
6. Phentermine: A stimulant that suppresses appetite and boosts energy. It’s typically prescribed for short-term use (up to 12 weeks) due to potential for dependence.
7. Metformin: An oral diabetes medication that can aid in weight loss by reducing glucose production and improving insulin sensitivity. It’s often used off-label for weight management in non-diabetic patients.
8. Xenical (orlistat): A lipase inhibitor that reduces fat absorption in the intestines. It’s available by prescription at a higher strength than its over-the-counter counterpart, Alli.
9. Contrave (naltrexone/bupropion): A combination medication that affects the central nervous system to reduce appetite and food cravings. It combines an opioid antagonist with an antidepressant for weight loss.
10. Victoza (liraglutide): Another GLP-1 receptor agonist similar to Saxenda but at a lower dose. It’s primarily used for type 2 diabetes management but can also aid in weight loss.

Natural Weight Loss Methods

Dietary Changes:
Changing your eating habits is the foundation of natural weight loss. Eating a nutrient dense, calorie conscious diet can produce big results. This means increasing whole foods, lean proteins and fibre rich vegetables and decreasing processed foods and added sugars. Portion control and mindful eating can also enhance the effectiveness of dietary changes.

Herbal and Nutritional Supplements:
The weight loss supplement market is huge but scientific evidence for many products is limited. Some natural compounds like green tea extract, conjugated linoleic acid (CLA) and garcinia cambogia have shown promise in small studies. But always approach supplements with caution and consult a health professional as large scale, long term clinical trials are often lacking.

Lifestyle and Behavioural Changes:
Sustainable weight loss often requires a holistic approach that goes beyond just diet. This can include:

1. Regular exercise: Cardio and strength training.
2. Stress management: Meditation, yoga or deep breathing exercises.
3. Adequate sleep: 7-9 hours of quality sleep per night.
4. Mindfulness: Being aware of eating triggers and emotional connections to food.
5. Social support: Surround yourself with like minded people or join a support group.

These lifestyle changes help with weight loss and overall health and wellbeing. Remember the most effective approach is often a combination of these that suits you and your lifestyle.

Choosing the Right Saxenda Alternative

Your Health Profile

Before you start any weight loss medication, you need to have an open and honest conversation with your doctor. This conversation should cover:

• Your full medical history including any chronic conditions
• All current medications and supplements you are taking
• Any known allergies or reactions to medications
• Family history of certain conditions especially those related to weight or metabolism

This will allow your doctor to assess the risks and interactions and make sure the chosen weight loss approach is safe for you. Be prepared to have some health screenings or tests to rule out any underlying conditions that may affect treatment.

Remember your health status is not static. You need to keep communicating with your doctor throughout your weight loss journey. Any new symptoms, side effects or changes in your overall health should be reported immediately as they may require changes to your treatment plan.

Defining Realistic Weight Loss Goals

When it comes to weight loss, setting goals is key to long term success. Here’s how to do it:

1. Work with your doctor to set realistic health focused goals
2. Understand that sustainable weight loss is 0.5 to 1 kg (1 to 2 pounds) per week
3. Focus on overall health improvements not just numbers on the scale
4. Consider non-weight related goals such as more energy or improved fitness
5. Be prepared for plateaus and understand weight loss is not always linear

Setting realistic goals is crucial not only to lose weight but also to maintain weight loss over the long term.

Your doctor will work with you to create a plan tailored to your individual health needs and weight loss goals. This may include medication, diet, exercise and behaviour change. Remember the goal is health and wellbeing not just weight loss.

Saxenda Vs Other Medications (Ozempic, Wegovy, Mounjaro)

Here’s a comparison of Saxenda with other injectable medications for weight management and diabetes:

Saxenda (liraglutide)

• GLP-1 receptor agonist
• Daily injection
• FDA-approved for weight loss in adults and adolescents (12+)
• Lower dose version (Victoza) used for type 2 diabetes

Ozempic (semaglutide)

• GLP-1 receptor agonist
• Weekly injection
• Primarily approved for type 2 diabetes
• Often used off-label for weight loss
• Lower dose than Wegovy

Wegovy (semaglutide)

• Same active ingredient as Ozempic (semaglutide)
• Weekly injection
• Higher dose than Ozempic
• Specifically approved for chronic weight management in adults

Mounjaro (tirzepatide)

• Dual GIP and GLP-1 receptor agonist
• Weekly injection
• Approved for type 2 diabetes
• Shows significant weight loss effects in clinical trials

Zepbound (tirzepatide)

• Same active ingredient as Mounjaro (tirzepatide)
• Weekly injection
• Specifically approved for chronic weight management in adults
• Higher doses available compared to Mounjaro

Key Differences: FDA Approved

1. Frequency: Saxenda is daily; others are weekly.
2. Mechanism: Saxenda and Ozempic/Wegovy are GLP-1 agonists; Mounjaro/Zepbound are dual GIP and GLP-1 agonists.
3. Potency: Newer medications (especially tirzepatide) have shown more significant weight loss in trials.
4. Indications: Some are primarily for diabetes (Ozempic, Mounjaro), while others are specifically approved for weight loss (Wegovy, Zepbound, Saxenda).
5. Age groups: Saxenda is approved for adolescents; others are currently only for adults.
6. Side effects: While similar, the profile and intensity can vary between medications.
7. Cost and insurance coverage may differ significantly between these options.

FAQ

Here are 10 frequently asked questions (FAQs) about top natural Saxenda alternatives available over the counter, including liraglutide equivalents and substitutes:

What are the best natural alternatives to Saxenda available over the counter?
Popular natural alternatives include PhenQ, Glucomannan, Green Tea Extract, Conjugated Linoleic Acid (CLA), and Garcinia Cambogia. These supplements aim to support weight loss through various mechanisms like appetite suppression and metabolism boosting.

How do these natural alternatives compare to Saxenda in terms of effectiveness?
While natural alternatives may offer some benefits, they typically don’t match the potency of prescription medications like Saxenda. Results can vary significantly between individuals and are generally more modest than those seen with Saxenda.

Are over-the-counter alternatives safer than Saxenda?
Natural alternatives often have fewer side effects than prescription medications. However, “natural” doesn’t always mean safe for everyone. It’s important to consult with a healthcare provider before starting any new supplement regimen.

Can I take multiple natural supplements together to enhance weight loss effects?
While it’s possible to combine some supplements, it’s crucial to do so under professional guidance. Some combinations may lead to adverse interactions or excessive stimulant effects.

How long does it typically take to see results with natural Saxenda alternatives?
Results can vary, but most people may start noticing changes within 4-8 weeks of consistent use, combined with a healthy diet and regular exercise.

Are there any natural supplements that specifically mimic the action of liraglutide (the active ingredient in Saxenda)?
While no natural supplement exactly replicates liraglutide’s effects, some like Berberine have been studied for their potential to influence blood sugar and metabolism in ways that may support weight loss.

Do I need a prescription for these natural alternatives?
No, the natural alternatives mentioned are typically available over the counter without a prescription. However, always check local regulations as they can vary by region.

Can these natural alternatives help with diabetes management like Saxenda does?
Some natural supplements, like Berberine or Cinnamon extract, have shown potential in supporting blood sugar management. However, they should not be considered a replacement for diabetes medications without consulting a doctor.

Are there any dietary or lifestyle changes I should make alongside taking these supplements?
For best results, combine these supplements with a balanced, calorie-controlled diet and regular physical activity. Lifestyle changes are crucial for sustainable weight loss.

How do the costs of natural alternatives compare to Saxenda?
Natural alternatives are generally much less expensive than prescription medications like Saxenda. However, costs can add up if taking multiple supplements, and insurance typically doesn’t cover over-the-counter products.