Also known as anti-estrogens, estrogen blockers are supplements or medications that prevent the cells from creating or using estrogen (the female sex hormone).
Women often use estrogen blockers because some research suggests they may help prevent breast cancer.
Men use the blocker supplements because high levels of female hormones can cause man boobs (gynecomastia), weight gain, fatigue, loss of muscle mass, erectile dysfunction (ED), and many other problems.
In this article, we are going to concentrate on the negative ways high estrogen can affect men and provide information about the best estrogen blocking supplements available to buy over the counter (OTC).
If you are already suffering from issues related to high levels, you will be keen to find a quick solution. We understand that so we will introduce the best brand supplements first.
After the introductions are out of the way, we will take a closer look at the reasons that can cause high estrogen in men and the additional steps men can take to reduce it quickly.
The Top 4 Estrogen Blocking Supplements Revealed
After reviewing the abilities of dozens of popular antiestrogens, we were able to find the products that work best.
Based on their ingredient profiles, customer reviews, and other important ranking factors, here are the four male estrogen blockers that came out on top.
- PrimeGenix Dim3x – best estrogen blocker for men
- Testo Prime – best testosterone booster OTC
- Testonine – boost male androgenic performance
- Prime Male – t-booster for older males
Dim3X sits at the top of the list because it’s the most effective estrogen blocking supplement for men.
The other top 3 estrogen reducing supplements are primarily intended to function as testosterone boosters.
In addition to providing ingredients that encourage increases in natural testosterone, these premium supplements also contain compounds that block non male hormones.
Their abilities in this area actually outshine the capabilities of most supplements that have blocking estrogen as a primary goal.
Due to the positive influence the other three supplements have on testosterone, depending on your circumstances and body ambitions, you may find that the other top 3 supplements are a better fit for your needs.
#1 – Dim3x – Top Estrogen Blocker Supplement
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Dim3X is a high-quality estrogen blocker intended for men who need a supplement to control the hormonal changes that occur due to aging.
Like all the best over the counter estrogen blocking supplements, it hinders a process known as aromatization.
Aromatization occurs when the enzyme aromatase converts testosterone to estrogen. In addition to elevating levels, the process lowers circulating testosterone.
This is a big part of the reason why men who have high estrogen experience so many problems. And that’s not surprising. Testosterone is the male sex hormone, after all.
Dim3X is an unusual name for a supplement but the name is based on the key ingredient. It’s DIM. The “3X” refers to the triple-advanced delivery system that enhances the bioavailability of DIM.
Dim3X has excellent customer reviews. Once you understand how the supplement works, you shouldn’t find this surprising and, as it has already helped so many other men, there is no reason why Dim3X cannot do the same for you too.
You have nothing to lose by ordering this excellent supplement because the manufacturer provides a 67-Day Money-Back Guarantee.
How Dim3X Reduces Estrogen and Benefits Male Healthy Hormonal Balance
- Metabolizes estrogen
- Supports testosterone levels
- Reduces body fat
- Preserves lean muscle mass
- Increases strength and stamina
- Enhances physical performance
- Improves mood, focus, and concentration
Dim3X Natural Estrogen Blocker Ingredients
Regardless of whether you are already keen to try Dim3X or you are still sitting on the fence, you need to take a look under the hood to fully understand what makes this supplement tick.
DIM – Diindolylmethane/3,3′-Diindolylmethane
DIM (Diindolylmethane/3,3′-Diindolylmethane) is a compound that’s present in cruciferous vegetables such as broccoli, cabbage, cauliflower, and kale. It’s also one of the most-studied natural estrogen blockers in the world.
The link between high female hormone levels and thyroid diseases and breast cancer in women is well known. That’s why scientists have already devoted so much time to exploring the hormone-blocking capabilities of DIM.
Thyroid cancer in women is 4-5 times higher in women than it is in men. Some of the best scientific minds in the world believe this is due to women having more feminine hormones than men do.
Once you are aware of the statistics, it is easier to understand why most of the studies involving DIM have been carried out on women. When it comes to issues caused by high estrogen, they really do appear to have got the short end of the stick.
One of the early studies evaluating the antiestrogenic abilities of DIM was conducted on women suffering from thyroid proliferative disease (TPD).
Seven women (aged 39–56 years) took part and received DIM supplements daily. The study ran for 14 days.
The researchers monitored the women’s response to DIM in several ways, including urine sampling. The results of this showed DIM was successful in modulating estrogen metabolism.
Additional data, some of which was obtained via thyroid tissue sampling, also confirms DIM’s value as an ingredient in estrogen blocking supplements. [1]
Research is also supportive of using DIM to support good prostate health.
Prostate issues affect many aging men. DiM’s ability to offer help in this area provides Dim3X with additional value as a supplement for men. [2]
AstraGin
AstraGin is a proprietary ingredient that consists of Astragalus root and San-qi Ginseng Root.
Although both herbs have medicinal value in their own right, this special pairing is designed to increase ingredient absorption. AstraGin is the main player in the Dim3x, 3X delivery system. [3]
BioPerine
BioPerine is a high-potency black pepper extract that is standardized to be 95% piperine. In its natural form, black pepper is less than 10% piperine and the amount per serving is apt to vary.
Piperine is the alkaloid that gives black pepper its distinctive smell. Although piperine is associated with several health benefits, supplement manufacturers usually add it to their products because it increases the bioavailability of the other ingredients present in their formulations.
In addition to being present in many supplements, piperine is also used to enhance the bioavailability of certain prescription medications.
Piperine typically enhances absorption rates by 30-200%. [4]
Vitamin E
Limited research suggests Vitamin E may have estrogen-reducing capabilities but there is still much to learn. If it can do it, that’s a bonus but DIM is more than capable of going it alone.
However, vitamin E adds extra value to the Dim3X formulation by functioning as a testosterone booster. [5]
Dim3X Pros and Cons
Pros
- The most powerful estrogen blocking supplement for men
- Provides one of the best-studied estrogen blockers
- Has an advanced delivery system that enhances ingredient potency
- Excellent customer reviews
- No known side effects
- 67-day money-back guarantee
Cons
- You can only buy it from the official website
#2 – Testo Prime – Increases Testosterone levels
CLICK to view Testo Prime price and current special offers
Testo Prime is another high-quality over the counter supplement that blocks estrogen. However, this option primarily functions as a testosterone booster. It’s very popular with aging men who are seeking relief from the symptoms of andropause (male menopause).
Most testosterone boosters are aimed at bodybuilders and have been specially formulated to enhance training ability and muscle growth.
Testo Prime has value in these areas too but is primarily geared toward helping aging men to overcome fatigue, low libido, ED, and unfavorable changes in body composition. Testo Prime is one of the best anti-aging supplements that men can use.
Too much female hormone contributes to such problems. That’s why Testo Prime contains some of the best natural estrogen blockers for men.
Men who have experience using Testo Prime have nothing but good things to say about it and affirm it has changed their lives for the better.
In addition to being one of the best estrogen blocking supplements for men, Testo Prime also boasts an unbeatable money-back guarantee. It’s good for life so, if you don’t get the results you are seeking, you can claim a refund instead.
Testo Prime Benefits to Healthy Hormonal Balance
- Boosts natural testosterone
- Blocks excess estrogen and restores hormonal balance
- Burns body fat
- Increases muscle mass and strength
- Helps with energy and endurance
- Improves libido and overall sexual health
Testo Prime Ingredient and How They Balance Hormone Levels
Testo Prime provides two of the best natural ingredients for restoring estrogen balance – green tea and pomegranate.
Green Tea
Research proves green tea polyphenols can inhibit the activity of aromatase, preventing the testosterone to estrogen conversion. [6]
Green tea’s abilities in other areas have also been subjected to much study. Especially its ability to support weight loss. There is a mountain of research that proves green tea is a thermogenic fat burner that works.
Pomegranate
Rich in antioxidants, pomegranate fruit extracts support good health in several ways. One of the things they do is help clear arterial plaque.
Pomegranate extracts are also one of the best natural selective estrogen receptor modulators (SERMs). [7]
SERMs bind with estrogen receptor ligands. By doing so, they prevent estrogen receptors from binding with estrogen. The upshot of this is, even when circulating estrogen levels are high, there is not a lot the hormone can do. If it can’t find a receptor to bind with, it may as well not be there.
Additional Ingredients
Testo Prime also contains several of the best natural testosterone boosters including zinc, Panax ginseng, Ashwagandha, and fenugreek.
In addition to being a proven testosterone booster, fenugreek may also help prevent skin aging. It’s a good all rounder that has a lot to offer menopausal men. [8, 9]
Testo Prime Positives and Negatives
Pros
- The best estrogen blocker for andropause
- Provides 2 proven estrogen blockers
- Contains Bioperine to improve ingredient absorption
- Also contains several testosterone boosters
- Provides natural aphrodisiacs
- Excellent customer reviews
- No known side effects
- Lifetime money-back guarantee
Cons
- You can only buy it from the official website
#3 – Testonine – Naturally Boosts Testosterone Levels
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A powerful testosterone booster, Testonine also has added value as an estrogen blocker.
Testonine places a greater focus on enhancing muscle growth than the previous two supplements. It’s presently the best supplement for blocking estrogen and aiding improvements in overall body composition.
If you like to train hard and are shooting for your ultimate physique, Testonine can help you to do it.
Greater levels of circulating testosterone can result in increased dangers of high estrogen due to aromatization. That’s why Testonine contains aromatase inhibitors.
To put it simply, Testonine is designed to send your natural testosterone through the roof and then keep it there without you having to worry about high estrogen or aromatization.
Testonine Benefits
- Naturally boosts testosterone levels
- Inhibits estrogen production
- Restore hormone balance
- Improves muscle growth
- Reduces body fat metabolism
Testonine Ingredient Highlights
Testonine is a complex product. It contains 18 ingredients, all of which boast abilities that are backed by science.
Although many of them are present to stimulate increases in testosterone, licorice, and nettle are included to regulate estrogen metabolism.
Licorice
Licorice provides isoliquiritigenin which has been shown to produce a 50% reduction in aromatase gene expression. The bottom line is, if you have a lot of testosterone circulating in your blood, licorice will help keep it there.
This ability is well known, Many women use licorice to control the symptoms of menopause but, with a powerful aromatase inhibitor such as this, they need to tread carefully.
However, licorice’s ability to protect against aromatization makes it a perfect choice for men. [10]
Nettle
Gardeners consider the stinging nettle (Urtica dioica) a weed so they generally unearth it and evict it from their gardens.
However, there is more to the stinging nettle than most people think. Not only is it edible (when prepared properly) but this “weed” also boasts a nutritional content that’s greater than spinach, kale, or asparagus.
Needless to say, Testonine does not provide nettle extracts for its nutritional content. Nettle is present in the formulation because it’s one of the best natural estrogen inhibitors.
Nettle controls estrogen by providing the aromatase inhibitor Hydroxy-10,12-octadecadienoic acid. [11]
Going a step further, nettle also helps keep free testosterone levels high by preventing it from binding with SHBG (sex hormone-binding globulin).
Additional Anti Estrogen Aromatase Inhibitor Ingredients
Like Testo Prime, Testonine takes advantage of the testosterone-boosting abilities of zinc and Panax ginseng. It also provides Tongkat ali and maca. Both these herbs deliver notable increases in testosterone, performance, and muscle growth.
The formulation has L-arginine in it too, along with several other ingredients that are renowned for their abilities to enhance training capacity and muscle mass.
Testonine Pros and Cons
Pros
- Powerful testosterone booster
- Blocks aromatase
- The best male estrogen blocker for men seeking muscle growth
- No known side effects
- 100-day money-back guarantee
Cons
- You have to buy it from the official website
- It’s unsuitable for vegans or vegetarians (contains oyster extract)
#4 – Prime Male – For Testosterone Deficiency
CLICK to view Prime Male pricing and special offers
Although it didn’t make it to the top of our list, Prime Male still has an awful lot to offer, both as an estrogen blocker and to restore hormonal balance and boost testosterone levels.
Dolph Lundgren uses this supplement and gives it a very strong endorsement. The Hollywood He-Man hasn’t got enough good things to say about the product.
With over 60 years on the clock, Dolph’s looking very good for his age, still does a lot of his own stunts, and says Prime Male helps him to train harder and feel more positive and energetic. It’s a strong endorsement and plenty of other men are saying the same.
Prime Male is another supplement that’s aimed at active men who like to keep fit. Like Testonine, it stimulates increases in testosterone while also providing ingredients that are natural anti-estrogen.
The only thing that lets this option down is the lack of a money-back guarantee. All the other supplements that work best for blocking estrogen have one. Prime Male is the only one that does not.
Prime Male Benefits
- Boosts testosterone production
- Blocks the conversion of testosterone to estrogen
- Enhances mood, libido, and sexual function
- Improves energy
- Supports muscle mass
- Turns back the clock on aging
Prime Male Ingredient Highlights
The anti-estrogen capabilities of Prime Male are mostly due to Damiana. However, saw palmetto makes a reasonable second fiddle.
Damiana
Damiana (Turnera diffusa) is a shrub that grows wild in Mexico. The ingredient used in supplements comes from its leaves.
Damiana leaves provide pinocembrin 1 and acacetin 3. These natural plant compounds block estrogen by inhibiting activity the activity of aromatase. [12]
Saw Palmetto
Saw palmetto (Serenoa repens) doesn’t stop testosterone from converting to estrogen but it does appear to limit the effect the hormone has on the body by reducing the number of estrogen receptors available for it to bind with.
The ingredient further protects circulating testosterone levels by preventing it from converting dihydrotestosterone (DHT).
Additional Ingredients
The Prime Male formulation is home to several natural testosterone boosters. By now you may not be surprised to learn zinc and Panax ginseng and listed among them. Certain ingredients turn up again and again. Manufacturers favor them because there is so much evidence that proves that they work.
Prime Male also provides Maca and Tribulus. These are two more botanical ingredients that have good reputations as testosterone boosters.
Prime Male Pros and Cons
Pros
- Boosts testosterone
- Prevents aromatization
- Balances hormones
- Compensates for age-related hormonal imbalances
- Endorsed by Dolph Lundgren
- No known side effects
Cons
- You can only buy it from the official website
- There is no money-back guarantee
What Causes High Estrogen In Men?
Several things can push up men’s estrogen levels and cause them to become too high. However, regardless of the cause, the best OTC estrogen blocking supplements can help.
However, where high female hormones are due to lifestyle choices, it makes sense to address these issues as well instead of relying on inhibitors or blockers to provide damage control.
Aging
The aging process brings about many changes in the male body. After adolescence, testosterone production goes into a slow decline. With each passing year, men’s bodies produce less and less. By the time they reach 40, the effects of this often become apparent.
Many other hormones are also in lesser supply, including human growth hormone (HGH). Unfortunately, it’s a little different with estrogen. Levels are more likely to rise than they are to go into decline.
Aromatization –
Nothing new here. We’ve explained this problem before. The body is home to an enzyme called aromatase that causes testosterone to convert to estrogen.
Aromatization is one of the main reasons men experience high estrogen. Fortunately, DIM can prevent this from happening. So can certain other natural ingredients but DIM offers the greatest potential.
Poor Diet – Increased Body Fat
Food choices can also influence the level of estrogen present in men. When people eat too many of the wrong kinds of foods or just too much in general, it causes weight gain.
Body fat houses the aromatase enzyme. So, the more fat you have, the higher your estrogen levels are likely to become.
Belly fat is particularly bad for this. If you have a lot of fat around your midsection, the risk of estrogen dominance is much greater than if you were to have fat deposited in other areas of your body.
Unfortunately, none of us get to choose where fat cells develop. Our bodies have to follow the rules written in our DNA. However, when the majority of men gain weight, most of the fat is likely to be around their bellies.
Stress
There are lots of reasons to try and avoid stress. It’s harmful in so many ways. During periods of stress, the body produces extra cortisol. It’s a stress hormone that causes havoc in the body.
Among other things, cortisol can contribute to weight gain. It also suppresses testosterone but has the opposite effect on estrogen.
There are many ways to try and control stress including, yoga and meditation. Some stressed-out individuals find they feel much better after doing sports or taking an evening stroll.
Certain natural ingredients, such as Panax ginseng, are good for controlling stress too. As you may recall, this ingredient is present in three of the top estrogen blocking supplements.
Testosterone Replacement Therapy (TRT)
When men experience fatigue, ED, or other symptoms of low testosterone, doctors often offer them TRT. The treatment is available in many forms including injections, gels, and testosterone skin patches.
Unfortunately, TRT can cause as many problems as it solves. Many men choose not to chance it.
One of the problems with TRT is it can take testosterone levels over the top, increasing the risk of aromatization.
Why Men Need Feminine Hormones
Men need feminine hormones for several reasons. Along with testosterone these hormones are crucial for male sexuality.
These feminine compounds help regulate men’s moods by stimulating serotonin (a feel good hormone) and beta-endorphins which are neurotransmitters that give us feelings of happiness and pleasure.
These same neurotransmitters are believed to help with verbal and spatial memory in men later in life.
Testosterone is king but the male body still needs these feminine hormones. Unfortunately problems arise when levels get too high.
You’re probably here because you’re looking for the best blockers for these hormones in men.
Effects of Feminine Hormone Levels in Men
Although these hormones are associated with women, men need them too. Problems only arise when levels get too high.
High levels can cause:
- Fatigue and energy loss
- Loss of muscle mass
- Weight gain
- Low libido
- Erectile dysfunction
- Fertility issues
- Gynecomastia (enlarged male breast tissue)
These can affect men’s lives big time. For example when high levels cause fatigue men can’t perform at work or in the bedroom. Even simple tasks like playing with kids can be a challenge. Men who experience this imbalance may also lose motivation and ambition.
These are just a few of the problems that can arise from hormonal imbalance in men. Using one of the top supplements to block these feminine hormones can help you get back in control.
Remember, while estrogen is essential, maintaining the right balance is key to optimal male health and well-being.
Estrogen Blockers Summary
Also known as female hormone antagonists and anti-feminine hormones, these inhibitors are products that regulate the main female sex hormone and prevent it from getting too high.
Some supplements are designed to reduce female hormone levels in men, but most of the top supplements for blocking this hormone are designed to increase testosterone – these inhibitors increase testosterone.
Naturally, by increasing testosterone, many popular T-boosters increase the risk of aromatization and high female hormone levels. As seen in our product reviews, our list of top feminine hormone blockers for men only includes options that increase testosterone without high levels of the main female sex hormone.
These inhibitors work by suppressing aromatase. They may also act on the receptors, making them less responsive to this hormone.
High aromatization always means low testosterone. It’s a double whammy.
But even without the female sex hormone interference, low testosterone is a problem that’s all too common in men 30 and above.
This is due to natural testosterone decline.
If you know your problems are estrogen related, Dim3X is the way to go. While a better one may come along in the future, Dim3X is the top estrogen blocker for men.
If you’re not sure if your problems are estrogen, low testosterone or both, you may be better off choosing one of the other three top supplements. Each one is slightly different and all of them work fast.
Should I Have Estrogen Level Tests: Yes or No?
As with testosterone, men that wish to do so can have their estrogen levels checked.
Some men go this route, while others prefer not to. However, it’s best to get your estrogen level tested if your doctor has suggested you do so.
Estrogen may be particularly important where certain conditions apply.
It’s a good idea to get tested if you are showing signs of high estrogen and are also:
- Anorexic
- Overweight or obese
- Suffering from chronic stress
- Using anabolic steroids
- Living with Klinefelter syndrome
- Diabetic
- Having problems with pituitary gland disorder
- Suffering from kidney or liver disease
You should also consider having your estrogen levels checked if you have a family history of high estrogen or are undergoing radiation treatment or chemotherapy (especially for prostate cancer).
Summary on Estrogen Blocker Supplements for Men
High estrogen can cause men a lot of problems including fatigue, low libido, and man boobs. It’s not an issue it is wise to ignore.
Depending on your circumstances, lifestyle modifications may go a long way to rectifying the problem.
However, although taking steps such as eating healthy and trying to avoid or control stress can be beneficial, such efforts are not always enough and will certainly do little to prevent issues such as aromatization.
Fortunately, all the best estrogen blocking supplements can tackle this issue. By doing so, they have already helped an untold number of men to reclaim their lives.
This article provides information about the four top options available otc and online. At the time of writing, Dim3x was the best estrogen blocking pill for men overall. It’s a powerful option that gets the job done and countless customer reviews show it.
Depending on your personal goals and circumstances, one of the other three top options may be a better fit for your needs. However, all of them block estrogen. If you have problems in this area, the most important thing is that you take action instead of simply crossing your fingers and hoping for the best.
Estrogen Blocking Research Sources and Clinical Data
1. DIM Modulates Estrogen Metabolism in Patients with Thyroid Proliferative Disease: A Pilot Study:
2. First Results of the Double-Blind Randomized Placebo-Controlled Multicenter Clinical Trial of Dim-Based Therapy Designed as Personalized Approach to Reverse Prostatic Intraepithelial Neoplasia (Pin):
3. AstraGin:
4. Bioavailability enhancers of herbal origin: An overview:
5. Effect of Vitamin E on Function of Pituitary-Gonadal Axis in Male Rats and Human Subjects:
6. Is Green Tea Drinking Associated With a Later Onset of Breast Cancer?:
7. Pomegranate Extract Demonstrate a Selective Estrogen Receptor Modulator Profile in Human Tumor Cell Lines and in Vivo Models of Estrogen Deprivation:
8. Effect of Fenugreek Extract Supplement on Testosterone Levels in Male: A Meta-Analysis of Clinical Trials:
9. Ethanolic Fenugreek Extract: Its Molecular Mechanisms against Skin Aging and the Enhanced Functions by Nanoencapsulation:
10. Licorice May Lower Sex Hormone Production, Reduce Fertility:
11. (10E,12Z)-9-Hydroxy-10,12-octadecadiensäure, ein Aromatase-Hemmstoff aus dem Wurzelextrakt von Urtica dioica: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/jlac.199119910158
12. Anti-aromatase Activity of the Constituents From Damiana (Turnera Diffusa) Male Estrogen Blocking Data 2023: https://pubmed.ncbi.nlm.nih.gov/18948180/
