As a professional who’s spent 3 decades in the anti-aging and longevity industry, I’ve been on a quest to find the most effective NAD+ supplements to support healthy aging.
NAD+ is a coenzyme that plays a crucial role in cellular energy production, DNA repair, and overall vitality.
As we age, our NAD+ levels naturally decline, leading to fatigue, cognitive decline, and other signs of aging. That’s why boosting nicotinamide adenine dinucleotide can be a game changer for anyone looking to maintain youthful energy and mental clarity.
After thorough research and personal experience, I’ve found the 3 best NAD+ supplements that are not only effective but also readily available over the counter and online.
Whether you’re new to the concept or looking to upgrade your current regimen, these supplements offer a convenient way to support your body’s natural anti-aging defenses.
Top 3 NAD Brands Over the Counter and Online
Here are the best brands currently on the market according to user reviews.
All 3 brands are available to order directly from the manufacturers website.
Best NAD+ Supplements Compared
#1 – Noocube NAD+
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What is Noocube?
Noocube NAD+ is an anti-aging supplement that boosts your body’s NAD+ levels which decline with age.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that supports energy production, DNA repair and overall cellular health.
Low NAD+ levels are linked to many age related issues such as cognitive decline, fatigue and weakened immune function.
By replenishing nicotinamide adenine dinucleotide levels Noocube helps to restore energy, improve cognitive function and healthy aging.
What’s in It? (Ingredients)
The main ingredient in Noocube is Nicotinamide Riboside Chloride (NR) , a form of vitamin B3 that has been scientifically proven to increase NAD+ levels more than other compounds.
NR is a precursor to NAD+ meaning it helps the body produce more of this molecule leading to more cellular energy, DNA repair and overall vitality.
Noocube NAD+ is:
- Vegan-friendly
- Gluten-free
- Nut-free
- No artificial colors and flavors
Why It’s the Best NAD Supplement and No. 1 Brand
Noocube NAD+ is the best and most popular NAD+ supplement for many reasons:
- Fast Acting Formula: Using Nicotinamide Riboside Chloride Noocube NAD+ increases NAD+ levels fast and you can feel the improvements in energy and cognitive function in as little as 2 weeks.
- Science Backed: The formula is based on the latest anti-aging research and clinical studies show that NR can increase NAD+ levels higher and faster than other boosters.
- Comprehensive Benefits: It’s not just for energy but also for cognitive function, immune health, DNA repair and metabolic function making it a full anti-aging solution.
- Trusted by Many: With over 299,434 purchases and 509,389 bottles sold Noocube is the top NAD+ supplement in the market backed by thousands of reviews from users who report increased energy, sharper mental focus and overall vitality.
- Sirtuin Activation: Higher NAD+ levels activate sirtuins enzymes linked to longer lifespan and cellular repair making Noocube the leader in anti-aging solutions.
Pros and Cons
Pros:
- Increases energy production by increasing NAD+ levels
- Improves cognitive function and mental clarity
- Supports DNA repair and overall cellular health
- Immune function and reduces inflammation
- Fast results: you can feel the improvements in 2 weeks
- Vegan, gluten-free and nut-free
- 60 day money back guarantee with free shipping worldwide
Cons:
- May cause mild digestive issues during the adjustment period for some users
- Daily supplementation required for continuous benefits
Where to Buy Noocube NAD Supplements
You can purchase Noocube NAD+ directly from the official website.
The website offers various package options, free worldwide shipping, and a 60-day money-back guarantee, ensuring you can try the product risk-free.
#2 – GenuinePurity Liposomal NMN
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What is GenuinePurity Liposomal NMN?
GenuinePurity Liposomal NMN is an NAD+ booster that helps support healthy aging by increasing NAD+ levels in your body.
NMN (Nicotinamide Mononucleotide) is the precursor to NAD+, and boosting NAD+ levels helps energy in cells, brain function and DNA repair.
Unlike regular NMN supplements, GenuinePurity uses liposomal technology to increase the absorption and bioavailability of NMN so more of it gets to your cells.
What’s in It? (Ingredients)
The main ingredient in GenuinePurity Liposomal NMN is Nicotinamide Mononucleotide (NMN), the direct precursor to NAD+ that can be converted into NAD+ in your cells within minutes.
What makes this formula different is the use of liposomal delivery, a technology that puts NMN in tiny fat-like particles to protect it from being broken down in the digestive system. This means better absorption and faster results.
Additional features:
- Non-GMO
- Gluten-free
- Vegan-friendly
- No artificial additives
Why It’s the No. 2 Choice
While GenuinePurity Liposomal NMN is a great supplement, it’s my expert opinion’s No. 2 NAD+ booster for the following reasons:
- Liposomal Technology: Liposomal delivery is better than regular NMN supplements. More NMN gets to your cells, which means more NAD+ production.
- Proven Benefits: NMN is researched for energy in cells, brain function and DNA repair. Research shows NMN supplementation can restore nicotinamide adenine dinucleotide levels and overall vitality and combat age related decline.
- Mitochondrial Support: NMN improves mitochondrial function which is critical for energy production and cellular health. As we age, mitochondrial efficiency decreases but NMN can help mitigate this and give you more energy and physical performance.
- Absorption Advantage: While it doesn’t have the rapid NAD+ elevation of Noocube NAD+, the liposomal technology in GenuinePurity means excellent NMN absorption making it one of the better NAD+ boosters for those who prioritize bioavailability.
- Popularity and User Feedback: GenuinePurity Liposomal NMN is well liked for its effectiveness, users report more energy, mental clarity and overall well being. It’s a favorite among those who prefer NMN over other NAD+ precursors like NR.
Pros and Cons
Pros:
- Liposomal delivery for better absorption and bioavailability
- Boosts NAD+ production for energy, brain function and DNA repair
- Mitochondrial support for physical and mental stamina
- Non-GMO, gluten-free and vegan-friendly
- No artificial additives
- High quality manufacturing
Cons:
- Slower results compared to some NR based supplements like Noocube
- Price: Liposomal NMN supplements are more expensive due to the technology used for absorption
- Consistency of use for best results
Where to Buy Liposomal NMN
You can buy GenuinePurity Liposomal NMN from their website or from other online retailers. Make sure to buy from a trusted source to get the real deal.
While GenuinePurity Liposomal NMN is my No. 2, it’s still a great option if you want to boost NAD+ with NMN and absorption and bioavailability is your top priority.
#3 – TRU NIAGEN
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What is TRU NIAGEN?
TRU NIAGEN is a clinically proven supplement designed to increase NAD+ levels and support healthy aging.
The key ingredient, Nicotinamide Riboside (NR), is a patented, highly bioavailable precursor to NAD+ that helps your cells produce more energy, repair DNA, and maintain optimal cellular function.
As NAD+ levels decline with age, TRU NIAGEN replenishes these levels, promoting cell regeneration and enhancing overall vitality.
What’s in It? (Ingredients)
The primary ingredient in TRU NIAGEN is Nicotinamide Riboside Chloride (NR), a unique form of vitamin B3 that has been extensively studied for its ability to safely and effectively boost NAD+ levels. NR is known for its superior bioavailability, meaning it is easily absorbed and converted into Nicotinamide Riboside Chloride within the body.
This makes TRU NIAGEN one of the most well-researched anti-ageing supplements available.
Other features of the product include:
- Non-GMO
- Gluten-free
- Vegetarian-friendly
- No artificial colors or flavors
Why It’s Ranked No. 3 NAD+ Brand
While TRU NIAGEN is a top-notch NAD+ booster, it ranks as No. 3 in my expert opinion for the following reasons:
- Patented and Well-Researched: TRU NIAGEN holds multiple patents on Nicotinamide Riboside (NR), and its effectiveness is supported by several clinical studies. This gives it a solid scientific backing, particularly for those looking for a proven, trusted product to increase NAD+ levels.
- Cellular Regeneration: By replenishing NAD+ levels, TRU NIAGEN promotes cell repair and regeneration. This makes it effective in fighting age-related decline, improving energy levels, and supporting overall cellular health.
- Long-Term Benefits: While the effects of TRU NIAGEN take longer to manifest compared to faster-acting supplements like Noocube, its use of NR ensures sustained, long-term NAD+ replenishment. This makes it a reliable choice for those seeking gradual but lasting improvements in their energy, cognitive function, and cellular vitality.
- Safe and Trusted: TRU NIAGEN is backed by FDA safety notifications and is GRAS (Generally Recognized As Safe) certified, meaning it’s trusted by health professionals and has a strong safety profile.
- Popularity and Satisfaction: With over 2 million bottles sold worldwide, TRU NIAGEN is a popular choice among users who report improvements in energy, mental clarity, and physical performance. However, its slower onset of results compared to higher-ranked supplements like Noocube and GenuinePurity Liposomal NMN places it in the 3rd position.
Pros and Cons
Pros:
- Clinically proven to elevate NAD+ levels with patented Nicotinamide Riboside (NR)
- Boosts cellular energy and supports DNA repair and regeneration
- Backed by multiple clinical studies and FDA safety notifications
- Long-term benefits for sustained NAD+ replenishment
- Non-GMO, gluten-free, and vegetarian-friendly
- Trusted and popular with millions of bottles sold
Cons:
- Slower onset of effects compared to faster-acting NAD+ boosters like Noocube
- Higher price point due to patented ingredient and extensive research
- Requires consistent, long-term use to see maximum benefits
Where to Buy TRU NIAGEN
You can purchase TRU NIAGEN directly from the official website or through major online retailers like Amazon. It’s important to buy from reputable sources to ensure product authenticity and quality.
While TRU NIAGEN ranks No. 3, it remains one of the most trusted and well-researched NAD+ boosters on the market. Its use of patented Nicotinamide Riboside ensures that you’re getting a safe, effective product that can help improve cellular health over time, making it a strong contender for anyone looking to boost their NAD+ levels for long-term vitality.
What is NAD+ and how does it relate to healthy aging
NAD+ (Nicotinamide Adenine Dinucleotide) is in every cell of your body and is involved in many biological processes, especially those related to energy production in the cell.
It’s a key player in taking nutrients from food and converting them into adenosine triphosphate (ATP) the molecule that powers the cell.
Beyond energy metabolism NAD+ is also involved in DNA repair, gene expression and inflammation regulation all of which are important for cellular health as we age.
As we age NAD+ levels decrease which can lead to decreased cellular function and contribute to many age related health issues such as decreased energy, cognitive decline and increased risk of chronic diseases like cardiovascular disease.
Metabolic Disorders and Neurodegenerative Diseases
This decrease in NAD+ is thought to be a major player in the aging process and lower levels have been linked to metabolic disorders, neurodegenerative diseases and reduced ability to repair damaged DNA.
Research has been emerging on NAD+ supplements and healthy aging.
These supplements aim to top up NAD+ levels which in turn may improve cellular energy, cardiovascular health and cognitive function. By increasing levels individuals may feel better overall, more resilient to age related stressors and potentially slower aging.
More research is needed to fully understand the long term effects of NAD+ supplementation but early studies suggest maintaining optimal levels could be a key to longevity and healthy aging making it an area of interest for those looking to improve their quality of life as they age.
NAD+ Supplements Benefits
Now that we know about NAD+ and healthy aging, it’s no surprise why nicotinamide adenine dinucleotide levels are so important for cellular health and overall health.
As nicotinamide adenine dinucleotide declines with age, nicotinamide adenine dinucleotide
supplements have become a way to combat that decline and support healthy aging.
Quality products top up your NAD+ stores and can bring many benefits for metabolic and physical health.
Boosting Cellular Energy and Vitality
One of the biggest benefits of NAD+ supplements is they boost cellular energy production.
As we mentioned earlier, nicotinamide adenine dinucleotide
is key to turning food into adenosine triphosphate (ATP), the molecule that fuels our cells.
By topping up NAD+ levels, these supplements can boost energy metabolism which can lead to improvements in physical endurance, mental clarity and feeling more alive as we age.
This is especially helpful for those who feel fatigued or experience energy dips as we get older.
Improving Metabolic Health and Insulin Sensitivity
Another benefit of NAD+ supplementation is its ability to improve insulin sensitivity. As the level declines, so does the body’s ability to regulate blood sugar.
This can lead to insulin resistance, a precursor to type 2 diabetes and other metabolic disorders. By topping up NAD+ levels, supplements can help the body respond better to insulin and reduce the risk of metabolic diseases and overall metabolic function.
Also NAD+ supplements have shown to support cardiovascular health. Nicotinamide adenine dinucleotide is key to maintaining endothelial cell function which is responsible for blood vessel health.
Supporting Cardiovascular Health and Potential Anti-Aging Benefits
By promoting healthy endothelial function these supplements can improve circulation, regulate blood pressure and reduce the risk of age related heart issues like cardiovascular disease.
There’s also emerging evidence that NAD+ supplements may have anti-aging effects at the cellular level. By supporting DNA repair, reducing inflammation and combating oxidative stress NAD+ may slow down some of the aging processes.
More research is needed to fully understand the extent of these anti-aging benefits but early results suggest that NAD+ supplements can reduce the impact of age-related cellular damage and lead to healthier aging and potentially longer life.
In summary NAD+ supplements bring many benefits from energy and metabolic health to cardiovascular support and anti-aging effects. By topping up declining nicotinamide adenine dinucleotide
levels these supplements can be a useful tool for optimal health and vitality throughout the aging process.
Choosing the Right NAD+ Supplement
When selecting a nicotinamide adenine dinucleotide supplement consider:
- Form – NMN or NR, both are effective precursors to NAD+ but may have slightly different benefits.
- Dosage – Make sure the product has the right dosage for your goals.
- Third Party Testing – Look for products that have been tested by a third party to verify purity and potency.
Always consult with a healthcare professional before starting any new supplement especially if you have pre-existing conditions or taking medications. Also look for products from reputable manufacturers that follow GMP.
NMN vs NAD+ Supplements: What’s the difference?
NMN (Nicotinamide Mononucleotide) and NAD+ both boost cellular energy and anti-aging, but they’re different in many ways:
- Molecular Structure: NMN is a precursor to NAD+, meaning it has to be converted into nicotinamide adenine dinucleotide
- in the body before it can be used. Nicotinamide adenine dinucleotide
- supplements aim to increase nicotinamide adenine dinucleotide
- levels directly, but often use NR (Nicotinamide Riboside) as an intermediate for better absorption.
- Bioavailability: NMN and NR differ in how well they’re absorbed by the body. NR, found in many NR supplements, has been studied more for its ability to raise nicotinamide adenine dinucleotide
- levels quickly and effectively. NMN’s bioavailability is still being studied, and some evidence suggests it might be slower or less efficient.
- FDA Status: NMN supplements are not FDA approved, so there’s questions around their regulatory status and long term safety. NR based NAD+ supplements are more widely available and have been studied in multiple clinical trials.
- Research and Efficacy: Both NMN and NAD+ precursors show promise in increasing NAD+ levels, but more research is needed to fully understand the efficacy and safety of NMN supplements, especially in human trials.
NAD+ Side Effects and Safety
NAD+ is generally safe for most people but some may experience mild side effects:
- Gastrointestinal upset
- Nausea
- Headaches
These side effects are usually minor and go away with continued use but more research is needed to know long term safety and effectiveness of NR supplementation.
Always consult with a healthcare provider before starting any new dietary supplements especially if you have existing health conditions or are taking medications. This will ensure the supplement is safe for you and won’t interact with your prescribed medications.
Expert Insights and Recommendations
Experts strongly advise consulting with a healthcare provider before beginning any new supplement, especially if you have underlying health conditions or are taking medications. This ensures that the supplement is safe and suitable for your individual health needs.
When selecting an anti aging supplement, look for products from reputable manufacturers that follow Good Manufacturing Practices (GMPs) and undergo third-party testing for quality and purity. These steps help guarantee that you’re getting a safe, effective product.
Although more research is needed involving human clinical trials to fully understand the long-term efficacy and safety of anti aging supplements, current evidence suggests that they may offer promising health benefits for healthy aging, cardiovascular health, and cellular energy support.
10 FAQs About the Best NAD+ Supplements
- What is NAD+?
NAD+ is a coenzyme vital for energy production, DNA repair, and overall cellular health. - What are the benefits of NAD+ supplements?
They boost energy, improve cognitive function, support anti-aging, and enhance cellular repair. - What’s the difference between NMN and NR?
NMN and NR are both NAD+ precursors, but NR is more researched and may be absorbed faster. - Are NAD+ supplements safe?
Generally, yes. Mild side effects like nausea or headaches may occur, but consult a doctor first. - How long does it take to see results?
Results can vary, but many users report improvements in energy and focus within 2–4 weeks. - What’s the best form: NMN or NR?
NR is more widely studied and may offer quicker NAD+ boosts, but both are effective. - Do NR supplements need to be taken daily?
Yes, daily supplementation is recommended to maintain elevated NAD+ levels. - Can I take NAD+ supplements with other vitamins?
Usually, yes, but consult with a healthcare provider to avoid potential interactions. - Are NAD+ supplements FDA-approved?
NMN is not FDA-approved, but NR-based supplements like TRU NIAGEN follow safety guidelines. - Where can I buy quality NAD+ supplements?
Look for products from reputable brands online or in stores that adhere to GMP standards and offer third-party testing.
